Antonio Muréna was born in Borgo Val di Taro, Italy. His family emigrated to France in 1923 and settled in Nogent-sur-Marne. His uncle gave him his first accordion and he began a performing career assisted by his cousin Louis Ferrari. Muréna played in cabarets and music halls from an early age.

In 1932 Muréna began to play the bandoneón in tango orchestras, including that of Rafael and Eduardo Bianco Canaro, at French clubs including La Boule Noire, Java, The Silhouette, Balajo (rue de Lappe), Pré Catelan and Ciro's. He also toured in South America, Germany, Italy and Switzerland. In 1949 he bought the Le Mirliton cabaret where he often played with Stephane Grappelli and Django Reinhardt. He also played with Matelo Ferret, Henri Crolla, Didi Duprat, Jo Privat and Gus Viseur. In 1958 he established the Radio Luxembourg Orchestra and also hosted the 36 Candles television show. He died in France